Ubiquinol | COQ-10 | Coq10

Topic	Description
Utility of CoQ10	Persuasive evidence has been provided to show that CoQ10 could help protect against a host of age-related disorders. Based on a vast volume of research, CoQ10 has emerged as one of today’s most popular dietary supplements. New delivery systems have been developed that transport more CoQ10 into the bloodstream than the previous versions. Providing greater quantities of Co-Q10 to the body is of great importance, as scientific studies show that higher CoQ10 blood levels produce greater benefits. In probably the most significant breakthrough in the history of the dietary supplement industry, a way has been discovered to deliver the highest concentrations of the most biologically active form of coenzyme Q10 to the bloodstream. This improved version of CoQ10 not only absorbs up to eight times better, but also has demonstrated anti-aging effects never known before. The ubiquinone form of CoQ-10 to be properly utilized, it first must be reduced in the body to its active metabolite which is called ubiquinol. While most ubiquinone is naturally reduced to ubiquinol, the optimal way to supplement with CoQ10 would be to orally take it in its ready-to-use ubiquinol form. Ubiquinol is very unstable, and it has been difficult to make it available as a dietary supplement. After many years of research, Japan’s largest producer of coenzyme Q10 has developed a patented method which is able to stabilize ubiquinol so that it can be ingested in capsule form.
Declining Ubiquinol Levels with Age	The reduced, active antioxidant form of Coenzyme Q10 (CoQ10) is known as Ubiquinol. It is generally produced within healthy bodies. Ubiquinol is CoQ10 that has been converted in order to be used in the cellular energy production process. It is indispensable for energy production, and is the strongest lipid-soluble antioxidant. Ubiquinol protects the body’s cells from oxidative stress which can damage proteins, lipids and DNA. The body has to convert ubiquinone into ubiquinol in order to generate cellular energy. Otherwise, the body’s energy production process cannot be completed and energy levels cannot be maintained. Hence, both are crucial to sustaining your body’s energy. That is why declines in ubiquinol means less cellular energy and less protection against oxidative stress. When this happens, free radicals are produced which damages the body’s cells, including proteins, lipids and DNA. Ubiquinol is necessary for a strong defense against this cellular oxidative damage and must be replenished to maintain good health. Several scientific reports indicate that sudden decreases in ubiquinone levels and increased oxidative stress are related to the aging process and with many age-related conditions. When young, you readily produce all of the CoQ10 you can use and easily convert it into ubiquinol. The main form of CoQ10 in the plasma and tissues of a healthy individual is, in fact, the reduced ubiquinol form. Factors like age can affect the body’s ability to produce and metabolize CoQ10. Some reasons may be increased metabolic demand, insufficient dietary intake, oxidative stress, etc. Some reports claim this decline becomes clear around 40 years of age, although it can begin as early as 20 for some. With age, supplementation with CoQ10 and/or ubiquinol becomes very important to maintaining optimum health.
Importance of Ubiquinol	Ubiquinol - New Improved Form of CoQ10 The amount of Coenzyme Q10 (CoQ10) absorbed is of great importance as higher CoQ10 blood levels provide many more benefits. Researchers found that Ubiquinol, the new form of CoQ10, was 40% more effective than conventional CoQ10 in slowing the aging process in mice. The actual video footage of the mice shows that the aging group of mice receiving no supplementation is unable to move or respond, developing lesions in and around the eye with spinal and limb deformities and a discolored coat. These pathological events are typical signs of degenerative aging suffered by humans. Aging mice supplemented with Ubiquinol, on the other hand, are alert, responsive and energetic with perfect health and youthful appearance. Coenzyme Q10 exists in both ubiquinol and ubiquinone forms, but they have majorly different roles to play in the body. For the first time in the market, a stabilized ubiquinol form of CoQ10 is available in capsule form. When compared to conventional (ubiquinone) CoQ10 supplements, the benefits of ubiquinol are far more great. A recent peer-reviewed study measured the absorption in humans supplementing with 150 mg and 300 mg of ubiquinol. Far less doses of ubiquinol produce about the same blood (plasma) levels compared with much higher doses of ubiquinone. In fact, it takes 8-times more ubiquinone to increase CoQ10 blood levels to what can be attained with much lesser doses of ubiquinol. Ubiquinol has an ability to stay biologically active in the body much longer. The greater absorption and ability to remain bioavailable over a greater sustained time period may mean unprecedented anti-senescent effects observed with new ubiquinol compared to ubiquinone. Benefits of Coenzyme Q10 Coenzyme Q10 is a critical component in the cellular energy production cycle. CoQ10 is produced in all cells of the human body. It helps produce cellular ATP (adenosine triphosphate), which supplies energy to all cell functions. Coenzyme Q10 is an antioxidant having great importance as a free radical scavenger. CoQ10 maintains the stability of the cell membrane, protects DNA from free radical induced oxidative damage, and promotes the recycle of Vitamin E in the body. The human body gradually loses its ability to synthesize CoQ10 with age. Research has proven that supplementation with CoQ10 may support normal heart function, protect DNA from free radical induced oxidative damage, promote and maintain healthy energy levels.
Benefits of Ubiquinol	Ubiquinol contributes to cardiovascular and cognitive health, increased energy and stamina, and overall health and wellbeing. It offers crucial antioxidant benefits and even regenerates other antioxidants, like Vitamin C and Vitamin E. Ubiquinol plays an important role in supplying energy to the organs such as the heart, kidneys, liver and lungs and may also help compensate for the age-related reduction in the body’s ability to convert CoQ10 into ubiquinol. It may help protect cells from free radical damage. It maintains your natural energy, health and youthful vigor at any age. Ubiquinol ignites the energy production in cells that gives energy to your vital organs. It protects your cells from the constant attack by free radicals. Your body produces this powerful antioxidant everyday when young. But its not possible to sustain your natural production forever, and so supplementation is important for healthy aging. In a study, aged rats were chosen to measure how long they could run on a treadmill. The control group using no CoQ10 showed a little decline in running times. The group receiving the ubiquinone form of CoQ10 had a 60% increase in running time whereas the group receiving ubiquinol had a 150% increase in running time. Type 2 diabetics suffer from elevated oxidative stress bringing about autonomic nervous system dysfunction. Japanese researchers proved that as the day proceeded, so did levels of oxidative stress. This oxidative stress depleted ubiquinol levels more rapidly than ubiquinone. In fact, diabetics had approximately 75% less ubiquinol than the non-diabetic control group. Researchers at the University of Tokyo found that people with certain types of liver disease including cirrhosis, hepatitis, and hepatoma, suffered from elevated oxidative stress which lead to a decrease in ubiquinol levels. This happened without any reduction in the levels of ubiquinone.
Answers to frequently asked questions	Q. What is ubiquinone or CoQ10? A. CoQ10 or ubiquinone is a vitamin-like substance present in every cell in the body. It is converted into a vital antioxidant and is crucial to energy production. Ubiquinone has been taken in supplement form by millions worldwide to increase energy, and improve cardiac and cognitive health. Ubiquinone protects cells from free radicals, regenerates other antioxidants and helps cells to generate the energy to fuel the vital organs in the body. Q. Isn’t ubiquinol another name for CoQ10? A. Ubiquinol is the active antioxidant form of ubiquinone, and is responsible for the powerful benefits associated with CoQ10. It is easily assimilated and utilized by the body. Preliminary research shows that ubiquinol is a lot more effective than ubiquinone at raising CoQ10 plasma level. Q. How do the two forms work in the body? A. Ubiquinone - whether produced naturally within the body or ingested - has to be converted into ubiquinol to generate cellular energy. Without proper conversion and optimal levels of both forms, the body cannot meet the constant and demanding energy needs of vital organs, or protect cells from harmful free radicals. Q. Can I produce and convert CoQ10 naturally? A. The body’s natural production of CoQ10 declines with age, as does the ability to convert the nutrient into ubiquinol. CoQ10 production may start to decline as early as age 20. In fact for some, CoQ10 levels within the heart and kidneys have dropped more than 25 percent by age 40. Q. Why are CoQ10 levels so important? A. A growing body of research associates maintaining healthy CoQ10 levels with optimal health of heart, neurological and immune systems. It is also linked with high levels of energy. As we age, maintaining the heart and nerves becomes more and more important. Additionally, cholesterol-lowering drugs such as statins can reduce CoQ10 levels, which can impact the quality of life for many of us. Q. If I feel fine healthwise, will a CoQ10 supplement be sufficient? A. In most of us, Ubiquinone supplements restore CoQ10 plasma levels to some degree, but its effectiveness generally begins to get less in those over 40 as a result of the diminished ability to convert the nutrient into ubiquinol. These diminished CoQ10 levels may have subtle effects initially that can become more pronounced with time. Q. Is it true that the new ubiquinol product is making the standard CoQ10 ubiquinone product obsolete? A. That is not true. The ubiquinone form of CoQ10, especially highly bioavailable forms like CoQsol-CF™, CoQ10 with Omega-3, and CoQ10 with Bioperine™ have so much solid data backing its efficacy. Most of clinical and experimental investigations have been done using ubiquinone, demonstrating its positive nutritional support in the fight against aging including angina pectoris, congestive heart failure, hypertension, and several other conditions. Also we can't forget that ubiquinone is an essential cofactor for the synthesis of ATP energy production. Thus both forms are necessary for efficient ATP production. So, CoQ10 (ubiquinone) will always be a vital supplement for maintaining a healthy lifestyle. Q. Which from of CoQ10 do I require? A. Healthy people under age 40 can meet their needs with the same CoQ10 supplements that have been used effectively for 30 years. Those over 40 should think of using the pre-converted, active antioxidant form. Q. What is the average recommended dosage? A. An initial dose is typically 200-300 mg per day for around three weeks, followed by a maintenance dose of 100 mg per day after that. Q. Can I use both ubiquinone and ubiquinol? A. Yes. Although great doses of CoQ10 are not suggested for healthy individuals, there have been many clinical studies to assess the safety and tolerability of high doses of CoQ10. In an ALS study, CoQ10 was safe and well tolerated in 31 subjects treated with doses as high as 3,000 mg/day for 8 months. NEUROLOGY 2005; 65: 1834-1836. Q. Why wasn’t ubiquinol previously available? A. Scientists identified ubiquinol’s crucial role in the body over 30 years ago. However, it took more than a decade of research, and advanced technology developed and patented by Kaneka Corporation, to isolate the compound outside the body.
More about Ubiquinol and Coq10	Ubiquinol and Coq10 help you reduce the signs of normal aging. They help you to feel more alert and responsive. They help maintain your vitality, by keeping blood levels high in Co Q10. They assist you to maintain blood pressure levels within the normal range. They promote healthy blood circulation in your body and thereby have a more efficient heart. Ubiquinol and Coq10 provide a boost to your immune system while promoting your healthy immune system. They help support your immune system by providing a defense against free radicals. They help support your nervous system and promotes an active mind. Your brain is one of the most active organs in your body and requires constant energy which they provide.
What you need to know about COQ-10?	Other names for COQ10 are Coenzyme Q10, Co Q10, Ubiquinone, Vitamin Q. CoQ10 is a naturally-occuring compound found in every cell in the body.
Apparent benefits of COQ10	Heart failure Cardiomyopathy Heart Attack Prevention High Blood Pressure Diabetes Gum Disease Kidney Failure Migraine Counteract Prescription Drug Effects Parkinson's disease Weight loss
What is the recommended dosage?	A typical CoQ10 dosage may be 30 to 90 mg per day, but spread over several doses, but depending on the circumstance the recommended amount can be as high as 200 mg per day. Since CoQ10 is fat-soluble it is better absorbed when taken with a meal that contains oil or fat. One thing to keep in mind is that the clinical effect is not immediate and may take up to 8 weeks.
Where can I purchase COQ10?	There are many popular nutritional companies that have their own formulations of COQ10, such as Jarrow Formulas, Bluebonnet and Life Extension. VNF Nutrition, online nutrional superstore, has a wide range of popular Ubiquinol brands and CO-Q10 for your requirements.

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